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Maggots
making medical comeback
By Lauran Neergaard
The Associated Press
Posted August 4 2004
WASHINGTON · Think of
these wriggly little creatures not as, well, gross, but as miniature
surgeons: Maggots are making a medical comeback, cleaning out wounds
that just won't heal.
Wound-care clinics around the country are giving maggots a try on
some of their sickest patients after high-tech treatments fail.
It's a therapy quietly championed since the early 1990s by a
California physician who's earned the nickname Dr. Maggot. But Dr.
Ronald Sherman's maggots are getting more attention since, in
January, they became the first live animals to win Food and Drug
Administration approval -- as a medical device to clean out wounds.
A medical device? They remove the dead tissue that impedes healing
"mechanically," FDA determined. It's called chewing.
But maggots do more than that, says Sherman, who raises the tiny,
wormlike fly larvae in a laboratory at the University of California,
Irvine. His research shows that in the mere two to three days they
live in a wound, maggots also produce substances that kill bacteria.
Still, "it takes work to convince people" -- including hospital
administrators -- that "maggots do work very well," said Dr. Robert
Kirsner, who directs the University of Miami Cedars Wound Center.
"They'll probably be easier to use now that they're FDA-approved,
and we'll talk about it more and think about it more," Kirsner said.
He estimates he uses maggots in about one in 50 patients where
conventional therapy alone isn't enough.
This has been quite a year for wormlike critters. In June, FDA also
gave its seal of approval to leeches, those bloodsuckers that help
plastic surgeons save severed body parts by removing pooled blood
and restoring circulation. And in the spring, University of Iowa
researchers reported early evidence that drinking whipworm eggs,
which causes a temporary, harmless infection, might soothe
inflammatory bowel disease by diverting the overactive immune
reaction that causes it.
There's a little more yuck factor with maggots. Most people know of
them from TV crime dramas, where infestations of bodies help
determine time of death.
Actually, maggots' medicinal qualities have long been known. Civil
War surgeons noted that soldiers whose wounds harbored maggots
seemed to fare better. In the 1930s, a Johns Hopkins University
surgeon's research sparked routine maggot therapy, until antibiotics
came along a decade later.
Today, despite precise surgical techniques to cut out dying tissue,
artificial skin and other high-tech treatments, hard-to-heal wounds
remain a huge problem. Diabetic foot ulcers alone strike about
600,000 people annually and lead to thousands of amputations.
Patients say it's not that hard to accept. Pamela Mitchell of Akron,
Ohio, begged to try maggots when surgeons wanted to amputate her
left foot, where infection in an inch deep, 2-inch-wide diabetic
ulcer had penetrated the bone. It took 10 cycles of larvae, but she
healed completely.
How did they feel? On day 2, when the maggots were fat, "I could
feel them moving, because they were ready to come out," she recalls.
But, "if you're faced with amputation or the maggots, I think most
people would try the maggots."
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